What Is PGT-SR?

PGT-SR (preimplantation genetic testing for structural rearrangements) is a laboratory test performed on embryos to detect chromosomal structural abnormalities such as translocations, inversions, or deletions.

Clinical significance

PGT-SR is recommended when one or both parents carry a known chromosomal rearrangement. Carriers of balanced translocations have a higher risk of producing embryos with unbalanced chromosomal arrangements, which can lead to implantation failure, miscarriage, or genetic conditions in offspring.

Common confusion

PGT-SR addresses structural rearrangements, not chromosome number (PGT-A) or single-gene disorders (PGT-M). Carriers of balanced translocations are often phenotypically normal but face reproductive challenges.

Related reference

/glossary/pgta →/glossary/pgt-m →/glossary/embryo-biopsy →/glossary/segmental-aneuploidy →/glossary/genetic-screening →← Back to Glossary Index

Used in

PGT-A →PGT-M →Embryo Biopsy →Segmental Aneuploidy →

This content defines terminology for educational orientation. It does not constitute medical advice.

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